Current Projects at the Dieli-Conwright Laboratory
A major theme of our laboratory is broadly the examination of Metabolic Dysregulation and Alterations in Body Composition through exercise-based energy balance interventions across the cancer continuum.
Within this context, we evaluate biomarkers linked to poor prognosis including metabolic dysregulation (i.e., insulin resistance, hyperglycemia) and negative changes of body composition (i.e., obesity, sarcopenia) and efficacy of exercise-based strategies to mitigate these biomarkers and treatment outcomes, across many of our investigations. Additional sub-themes of our laboratory include:
Within this context, we evaluate biomarkers linked to poor prognosis including metabolic dysregulation (i.e., insulin resistance, hyperglycemia) and negative changes of body composition (i.e., obesity, sarcopenia) and efficacy of exercise-based strategies to mitigate these biomarkers and treatment outcomes, across many of our investigations. Additional sub-themes of our laboratory include:
Metabolic Dysregulation, Inflammation, and the Immune Function
The AIM Trial: Taking AIM at Breast Cancer: Targeting Adiposity and Inflammation with Movement to Improve Prognosis in Breast Cancer Survivors (NCT04720209; PI: Dieli-Conwright)
The INHALE Trial: Feasibility and Preliminary Efficacy of Exercise during Immunotherapy in Patients with Lung Cancer (NCT06026111; MPIs: Kang, Kehl, Dieli-Conwright)
- Main Objective: To examine the effects of circuit-based vs. traditional aerobic and resistance exercise interventions on systemic and adipose tissue inflammation in early-stage, obese breast cancer survivors.
The INHALE Trial: Feasibility and Preliminary Efficacy of Exercise during Immunotherapy in Patients with Lung Cancer (NCT06026111; MPIs: Kang, Kehl, Dieli-Conwright)
- Main Objective: To examine the feasibility of high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT) in patients with lung cancer undergoing immunotherapy and preliminary efficacy on immune function.
Chemotherapy-Induced Cardiotoxicity and Cardiovascular Health
High Intensity Interval Training for Stage I-III Breast Cancer Patient Undergoing Anthracycline Chemotherapy (NCT02454777; PI: Dieli-Conwright)
- Main Objective: To examine the effects of a HIIT intervention on vascular function in early-stage breast cancer patients receiving anthracycline chemotherapy.
Chemotherapy-Induced Cognitive Impairments
The CLARITY Trial: Improving Cognitive Function Through High-Intensity Interval Training (HIIT) in Breast Cancer Patients Undergoing Chemotherapy (NCT04724499; PI: Dieli-Conwright)
The HYPE Trial: High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumors (NCT05740839; PI: Dieli-Conwright)
- Main Objective: To examine the effects of a HIIT intervention on cognitive function in early-stage breast cancer patients receiving chemotherapy.
The HYPE Trial: High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumors (NCT05740839; PI: Dieli-Conwright)
- Main Objective: To examine the effect of a virtually supervised HIIT intervention on cognitive, physical, and emotional health needs of young adult survivors of pediatric brain tumors.
Chemotherapy-Induced Peripheral Neuropathy and Immobility
The MOBILITY Trial: Exercise as a Preventive Agent to Combat Immobility in Patients with Ovarian or Endometrial Cancers Receiving Chemotherapy (NCT04997096; MPIs: Wright and Dieli-Conwright)
- Main Objective: To investigate the feasibility of a 16-week virtually supervised strength and aerobic training program in ovarian and endometrial cancer patients receiving first-line chemotherapy after surgery and its effects on lower extremity function.
Multimodal Energy Balance Approaches to Manage Symptom Management and Treatment Toxicity
The FASTER Trial: Pilot Study of the Impact of a Combined Intermittent Fasting and Exercise Intervention on Metabolic Markers in Patients with Advanced, Hormone Receptor-Positive Breast Cancer (NCT04708860; MPIs: Crane (Miami), Ligibel, Dieli-Conwright)
The VITALITY Trial: Exercise and Nutrition for Older Cancer Survivors and Their Caregivers (NCT TBD; MPIs: Crane (Miami) and Dieli-Conwright)
The DUO Trial: Modulating Immune-Microbiome Axis through High-Intensity Exercise and High-Fiber Diet for Immunotherapy Outcomes in Melanoma Patients (NCT06298734; PI: Kang)
The POWER-B Trial: Patient-Centered Surgical Prehabilitation for Patients undergoing Radical Cystectomy (PI: Mossanen)
- Main Objective: To examine the tolerability of a 12-week prolonged nightly fasting and exercise intervention in women with metastatic breast cancer and its impact on metabolic markers and quality of life.
The VITALITY Trial: Exercise and Nutrition for Older Cancer Survivors and Their Caregivers (NCT TBD; MPIs: Crane (Miami) and Dieli-Conwright)
- Main Objective: To improve cognitive and physical function among a racially and ethnically diverse sample of 764 older (≥65 years old) cancer survivor/caregiver dyads using a comparative effectiveness, non-inferiority randomized controlled trial testing two remotely delivered interventions (one supervised and one unsupervised) to increase exercise and adherence to a Mediterranean diet pattern.
The DUO Trial: Modulating Immune-Microbiome Axis through High-Intensity Exercise and High-Fiber Diet for Immunotherapy Outcomes in Melanoma Patients (NCT06298734; PI: Kang)
- Main Objective: To determine whether high-intensity exercise and high-fiber diet are feasible and improve various health outcomes among participants with advanced melanoma receiving immunotherapy.
The POWER-B Trial: Patient-Centered Surgical Prehabilitation for Patients undergoing Radical Cystectomy (PI: Mossanen)
- Main Objective: To determine the feasibility of a multifaceted nutrition and exercise prehabilitation program prior to radical cystectomy surgery in patients diagnosed with bladder cancer.
Exercise Interventions Tailored for Underrepresented Populations with Cancer
The ROSA Trial: Reducing Metabolic Dysregulation in Obese Latina Breast Cancer Survivors through Physical Activity (NCT04717050; PI: Dieli-Conwright)
The THRIVE Trial: Testing Home-Based Exercise Strategies to Improve Exercise Participation and Cardiovascular Health in Underserved Minority Patients with Cancer Undergoing Chemotherapy (NCT05327452; MPIs: Dieli-Conwright and Yan (UMass Boston)
The POWER Trial: Exercise to Enhance Cardiovascular Health among Black Prostate Cancer Patients with Androgen Deprivation Therapy (NCT05327465; PI: Dieli-Conwright)
The REMOVE Trial: Exercise for Tumor Suppressive Impact in Black Men with Prostate Cancer on Active Surveillance (NCT05918263; PI: Kang)
The COURAGE Trial: Exercise for Gut Microbiome in Patients with Young-Onset Colorectal Cancer Undergoing Chemotherapy (NCT06202183; PI: Dieli-Conwright)
- Main Objective: To examine the effects of a supervised exercise program and unsupervised exercise program on metabolic dysregulation in early-stage Latina breast cancer survivors.
The THRIVE Trial: Testing Home-Based Exercise Strategies to Improve Exercise Participation and Cardiovascular Health in Underserved Minority Patients with Cancer Undergoing Chemotherapy (NCT05327452; MPIs: Dieli-Conwright and Yan (UMass Boston)
- Main Objective: To determine whether a 16-week, home-based, aerobic and resistance exercise intervention will increase physical activity levels in Black and Hispanic breast, colorectal, or prostate cancer patients.
The POWER Trial: Exercise to Enhance Cardiovascular Health among Black Prostate Cancer Patients with Androgen Deprivation Therapy (NCT05327465; PI: Dieli-Conwright)
- Main Objective: To examine the effects of the exercise intervention on CVD risk factors assessed by the Framingham Risk Score in Black men on ADT for prostate cancer.
The REMOVE Trial: Exercise for Tumor Suppressive Impact in Black Men with Prostate Cancer on Active Surveillance (NCT05918263; PI: Kang)
- Main Objective: To examine the effects of a virtually supervised, aerobic exercise intervention on the biochemical progression of cancer in Black men with prostate cancer undergoing active surveillance.
The COURAGE Trial: Exercise for Gut Microbiome in Patients with Young-Onset Colorectal Cancer Undergoing Chemotherapy (NCT06202183; PI: Dieli-Conwright)
- Main Objective: To evaluate the effects of a 12-week virtual-based exercise intervention on the gut microbiome, chemotherapy toxicity, and treatment outcomes in survivors of young-onset CRC undergoing chemotherapy.
Blood Cancers and Treatment-Induced Abnormalities
The RESTART Trial: Impact of Exercise on the Complications of Corticosteroids in Patients with Graft-Versus-Host Disease following Allogeneic Stem Cell Transplantation (NCT05236062; PI: Dieli-Conwright)
The PROTECT Trial: Prehabilitation Exercise Training in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation (NCT05706766; MPIs: Dieli-Conwright and Marinac)
- Main Objective: To determine whether a 12-week, home-based, virtually supervised, aerobic and resistance exercise intervention is feasible in patients diagnosed with acute or chronic GVHD and whether it will improve glycemic control, body composition, physical fitness and function, and patient-reported outcomes.
The PROTECT Trial: Prehabilitation Exercise Training in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation (NCT05706766; MPIs: Dieli-Conwright and Marinac)
- Main Objective: To examine the effect of a prehabilitative aerobic and resistance exercise program on muscular strength in multiple myeloma patients scheduled to receive autologous stem cell transplant.
Advanced Disease and Skeletal Muscle Abnormalities
The RE-BUILD Trial: Resistance Exercise combined with Protein Supplementation for Skeletal Muscle Mass in People with Pancreatic Cancer undergoing Chemotherapy (NCT05356117; PI: Dieli-Conwright)
The FIERCE Trial: Debunking the Frailty-Sarcopenia-ADT Axis in Metastatic Prostate Cancer with Multicomponent Exercise (NCT06040125; PI: Dieli-Conwright)
- Main Objective: To determine whether an 8-week virtually supervised resistance exercise intervention combined with protein supplementation is feasible in pancreatic cancer patients initiating chemotherapy and if it will improve skeletal muscle mass.
The FIERCE Trial: Debunking the Frailty-Sarcopenia-ADT Axis in Metastatic Prostate Cancer with Multicomponent Exercise (NCT06040125; PI: Dieli-Conwright)
- Main Objective: To determine whether a 16-week supervised resistance, aerobic, and functional exercise intervention will improve frailty, sarcopenia, and disease progression in men with metastatic prostate cancer.
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©2020 Dieli-Conwright Laboratory at Dana-Farber Cancer Institute
©2020 Dieli-Conwright Laboratory at Dana-Farber Cancer Institute